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HRID 391025作成日：2026年10月26日

2,6-Difluoropyridine-4-boronic acid → 2-(2,6-Difluoro-pyridin-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

https://huagongshe.com/reaction/391025

反応式

関与物質

役割名称HCID仕込み量
反応物2,6-Difluoropyridine-4-boronic acidHCID 2762747—
反応物4-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholineHCID 23650837—
生成物2-(2,6-Difluoro-pyridin-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidineHCID 66934035—

反応手順

2-Chloro-4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)thieno[3,2-d]pyrimidine was reacted with 2,6-difluoropyridine-4-boronic acid in General Procedure A. Purification on silica yielded 2-(2,6-difluoro-pyridin-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08383620B2
出典データセットuspto-grants-2013_02
ORD IDord-822594e6964b4942ba041cb5406803d6
出典メモuspto-grants-2013_02