Cesium fluoride → 2-Amino-4-fluoromethyl-6-methoxypyrimidine

A mixture of 17.0 parts of 2-amino-4-chloromethyl-6-methoxypyrimidine, 59.5 parts of caesium fluoride and 130 parts of dry dimethylformamide was stirred under reflux for 2 hours. The mixture was cooled and evaporated in vacuo. The residue was taken up in ethyl acetate and the solution was washed four times with water. The organic phase was dried with anhydrous magnesium sulphate, stirred with decolourising charcoal, filtered and evaporated. The crude product was purified by chromatography on silica, eluted with ethyl acetate to give 2-amino-4-fluoromethyl-6-methoxypyrimidine m.p. 119°-121° C.

1. temperatureunder reflux for 2 hours
2. temperatureThe mixture was cooled
3. customevaporated in vacuo
4. washthe solution was washed four times with water
5. dry with materialThe organic phase was dried with anhydrous magnesium sulphate
6. stirringstirred with decolourising charcoal
7. filtrationfiltered
8. customevaporated
9. customThe crude product was purified by chromatography on silica
10. washeluted with ethyl acetate

ORDレコード

ord-57c87955e9ed4a11aa4e6f98c7716c2b

出典データセット

uspto-grants-1988_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04723006