p-Toluenesulfonate → (S)-2-Methyl-[1,4]bipiperidinyl
反応式
[C:1]([C@:8]1(C)[CH2:13][CH2:12][CH2:11][CH2:10][N:9]1[CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)(OC(C)(C)C)=O.S(C1C=CC(C)=CC=1)([O-])(=O)=O>>[CH3:1][C@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][N:9]1[CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1参加物
3
実験手順
The title compound was prepared in a manner substantially the same as intermediate (2S,31R)-2-Methyl-[1,3′]bipyrrolidinyl dihydrochloride by acid hydrolysis of BOC—(S)-2-Methyl-[1,4]bipiperidinyl which was synthesized by condensation of corresponding tosylate with (S)-(−)-2-methylpiperindine to get 1.37 g (94% yield) of the title product as a clear oil.
出典と根拠
- ORDレコード
- ord-c497a48b8897415ba28d5018287404bf
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08383814B2
反応ノート
読み込み中…