4-Aminoadamantan-1-ol → 4-{2-[3-(5-Hydroxy-adamantan-2-ylcarbamoyl)-phenoxy]-ethyl}-piperidine-1-carboxylic acid isopropylamide
反応式
[CH:1]([NH:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([CH2:13][CH2:14][O:15][C:16]2[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=2)[C:19]([OH:21])=O)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].[NH2:25][CH:26]1[CH:33]2[CH2:34][C:29]3([OH:36])[CH2:30][CH:31]([CH2:35][CH:27]1[CH2:28]3)[CH2:32]2>>[CH:1]([NH:4][C:5]([N:7]1[CH2:8][CH2:9][CH:10]([CH2:13][CH2:14][O:15][C:16]2[CH:24]=[CH:23][CH:22]=[C:18]([C:19](=[O:21])[NH:25][CH:26]3[CH:27]4[CH2:35][CH:31]5[CH2:30][C:29]([OH:36])([CH2:34][CH:33]3[CH2:32]5)[CH2:28]4)[CH:17]=2)[CH2:11][CH2:12]1)=[O:6])([CH3:2])[CH3:3]参加物
3
実験手順
Prepared from 3-[2-(1-isopropylcarbamoyl-piperidin-4-yl)-ethoxy]-benzoic acid and 4-amino-1-hydroxyadamantane. 1H NMR (400 MHz, CDCl3): δ 7.31-7.37 (m, 2 H), 7.23-7.26 (m, 1 H), 7.04 (dd, 1 H), 6.37 (d, 1 H), 4.18-4.24 (m, 1 H), 4.06 (t, 2 H), 3.98 (septet, 1 H), 3.90 (d, 2 H), 2.82 (t, 2 H), 2.17-2.29 (m, 3 H), 1.92-1.99 (m, 2 H), 1.73-1.86 (m, 11 H), 1.59 (d, 2 H), 1.19-1.30 (m, 2 H), 1.16 (d, 6 H).
出典と根拠
- ORDレコード
- ord-be130b41d4d24e5596290b10e2550638