Potassium Carbonate → Methyl 2-methoxy-5-(2-methyl-2H-tetrazol-5-yl)benzoate

HRID 391387ノート

反応式

HRID 391387 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[NH:17][N:16]=[N:15][N:14]=2)=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[C:18](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[N:15][N:16]([CH3:18])[N:17]=2)=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 178497409HCID 178497409、化合物

生成物 1

HCID 58993674Methyl 2-methoxy-5-(2-methyl-2H-tetrazol-5-yl)benzoate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Methyl 2-methoxy-5-(1H-tetrazol-5-yl)benzoate (0.78 g, 3.33 mmol) methyl iodide (0.21 mL, 3.33 mmol) and potassium carbonate (0.46 g, 3.33 mmol) were combined in acetone (8 mL) and heated at reflux overnight. After cooling to room temperature, the mixture was filtered and concentrated. Flash chromatography on silica gel afforded 170 mg (21%). LC/MS (HPLC method 3): tR=2.01 min, 249.09 (MH)+

後処理

  1. temperatureheated
  2. temperatureat reflux overnight
  3. filtrationthe mixture was filtered
  4. concentrationconcentrated
  5. customFlash chromatography on silica gel afforded 170 mg (21%)

出典と根拠

ORDレコード
ord-691639bd3bdf4813a313d45a95b577c9
出典データセット
uspto-grants-2013_02
特許番号
US08383821B2

反応ノート

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