(3-Bromo-5-nitrophenyl)methanol → (3-Amino-5-bromophenyl)methanol

関与物質

反応手順

(3-Bromo-5-nitrophenyl)methanol (3.9 g, 16.8 mmol) in methanol (35 mL) was flushed with nitrogen, and treated with platinum (IV) oxide (390 mg). The flask was flushed with hydrogen and allowed to stir under an atmosphere of hydrogen for 1 h. The reaction was flushed with nitrogen, filtered through celite, and concentrated to afford 3.1 g (94%). 1H-NMR (CDCl3, 300 MHz) δ 6.95 (s, 1H), 6.80 (s, 1H), 6.79 (s, 1H), 4.61 (s, 2H). Mass spec.: 203.96 (MH)+.

情報源と証拠