4-Chloro-6-(chloromethyl)pyrimidin-2-amine → 2-Amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride

HRID 3915

反応式

HRID 3915 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([CH2:9][Cl:10])[N:3]=1>C(OCC)C.Cl>[ClH:8].[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([CH2:9][Cl:10])[N:3]=1

参加物

4

反応物 1

HCID 201534884-Chloro-6-(chloromethyl)pyrimidin-2-amine

生成物 1

HCID 201535002-Amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 3283Diethyl Ether溶媒

実験手順

3.56 Parts of 2-amino-4-chloro-6-chloromethylpyrimidine was dissolved in 53 parts of dry diethyl ether and dry hydrogen chloride was bubbled through the solution, with stirring, until no further solid precipitated the solid was filtered, washed with ether and dried in vacuo. Recrystallisation from acetone gave 2-amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride m.p. 145°-150° C. (decomposition).

後処理

  1. customwas bubbled through the solution
  2. customprecipitated the solid
  3. filtrationwas filtered
  4. washwashed with ether
  5. customdried in vacuo
  6. customRecrystallisation from acetone

出典と根拠

ORDレコード
ord-58de8242ae774164a8154c623f6db4b7
出典データセット
uspto-grants-1988_02
特許番号
US04723006

関連ノート

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