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Dichloromethane → 1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 1-(1,3-Dioxaindan-5-yl)cyclopropane-1-carboxylic acid | HCID 14349608 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarbonyl chloride | HCID 59129154 | — |
反応手順
To an oven-dried round bottom flask containing 1-(benzo[d][1,3]dioxol-5-yl)-cyclopropanecarboxylic acid (A-8) (618 mg, 3.0 mmol) and CH2Cl2 (3 mL) was added thionyl chloride (1.07 g, 9.0 mmol) and N,N-dimethylformamide (0.1 mL). The reaction mixture was stirred at ambient temperature under an Ar atmosphere until the gas evolution ceased (2-3 h). The excess thionyl chloride was removed under vacuum and the resulting residue dissolved in CH2Cl2 (3 mL). The mixture was used without further manipulation.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524767B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-149e3eca1b604a8aa9b6b65372c7188b |
| 出典メモ | uspto-grants-2013_09 |