化工社化工社 化学情報印刷レポート · 研究参考用
5-Iodosalicylic acid → (s)-2-Hydroxy-5-{[5-({[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}carbonyl)pyridin-3-yl]ethynyl}benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Iodosalicylic acid | HCID 8388 | — |
| 反応物 | (S)-5-ethynyl-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide | HCID 24953136 | — |
| 生成物 | (s)-2-Hydroxy-5-{[5-({[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}carbonyl)pyridin-3-yl]ethynyl}benzoic acid | HCID 24953844 | 45% |
反応手順
In a manner similar to that describe in Example 434, a mixture of (S)-5-ethynyl-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide and 5-iodosalicyclic acid were reacted to give the title compound as a light tan solid (28 mg, 45%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383825B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-2ba09586f3944ac9adee28f74bc6abc9 |
| 出典メモ | uspto-grants-2013_02 |