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4-Iodobenzoic acid → (S)-4-{[5-({[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}carbonyl)pyridin-3-yl]ethynyl}benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Iodobenzoic acid | HCID 12085 | — |
| 反応物 | (S)-5-ethynyl-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide | HCID 24953136 | — |
| 生成物 | (S)-4-{[5-({[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}carbonyl)pyridin-3-yl]ethynyl}benzoic acid | HCID 24953845 | 49% |
反応手順
In a manner similar to that describe in Example 434, a mixture of (S)-5-ethynyl-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide and 4-iodobenzoic acid were reacted to give the title compound as a light yellow solid (30 mg, 49%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383825B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-649b2d01dafa46669fb54909a51f23a2 |
| 出典メモ | uspto-grants-2013_02 |