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tert-Butyl 3-ethynylphenylcarbamate → (S)-tert-butyl (3-{[5-({[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}carbonyl)pyridin-3-yl]ethynyl}phenyl)carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl 3-ethynylphenylcarbamate | HCID 11275982 | — |
| 反応物 | (S)-5-bromo-N-[methyl(oxido)phenyl--sulfanylidene]nicotinamide | HCID 86629466 | — |
| 生成物 | (S)-tert-butyl (3-{[5-({[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}carbonyl)pyridin-3-yl]ethynyl}phenyl)carbamate | HCID 24953492 | 23% |
反応手順
In a manner similar to that described in Example 449, tert-butyl 3-ethynylphenylcarbamate (0.098 g, 0.443 mmol) and (S)-5-bromo-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide (0.100 g, 0.295 mmol) reacted to give the title compounds as a white solid (32 mg, 23%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08383825B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-ee5b333ba71f4960bab3fcdacc19b949 |
| 出典メモ | uspto-grants-2013_02 |