Potassium Carbonate → Methyl 3-[4-(S-methylsulfonimidoyl)phenyl]propanoate
反応式
[CH3:1][S:2]([C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:13][CH:12]=1)(=[N:4]C(=O)C(F)(F)F)=[O:3].C([O-])([O-])=O.[K+].[K+]>CO>[CH3:1][S:2]([C:11]1[CH:12]=[CH:13][C:14]([CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:15][CH:16]=1)(=[NH:4])=[O:3]参加物
4
実験手順
Methyl 3-{4-[S-methyl-N-(trifluoroacetyl)sulfonimidoyl]phenyl}propanoate (0.200 g, 0.653 mmol) was dissolved in MeOH (3 mL). K2CO3 (0.450 g, 3.27 mmol) was added to the solution, and the resulting suspension was allowed to stir for 5 minutes. The suspension was filtered and the filtrate was concentrated. The residue was dissolved in EtOAc and dried over anhydrous anhydrous Na2SO4(s) to give the title compound (0.147 g, 93%).
後処理
- filtrationThe suspension was filtered
- concentrationthe filtrate was concentrated
- dissolutionThe residue was dissolved in EtOAc
- dry with materialdried over anhydrous anhydrous Na2SO4(s)
出典と根拠
- ORDレコード
- ord-51dab07d77ba41a885011de6cd0223f2
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08383825B2
反応ノート
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