Peracetic Acid → 6,7-Dihydro-5H-cyclopenta[b]pyridine 1-oxide

HRID 391784

反応式

HRID 391784 の反応式
[N:1]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.C(OO)(=[O:12])C>C(Cl)Cl>[N+:1]1([O-:12])[C:9]2[CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 6585Peracetic AcidHCID 68292Pyrindan

生成物 1

HCID 131533156,7-Dihydro-5H-cyclopenta[b]pyridine 1-oxide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

N-oxide formation also was performed under the following conditions. To a 6,7-dihydro-5H-[1]pyrindine solution in DCM at 0° C. was added peracetic acid (3 mL, 32% in AcOH), and the reaction was slowly allowed to come to rt and stirred for 12 h. The reaction mixture was diluted with DCM (5 mL) and washed with water, aq NaHCO3, brine, then dried over Na2SO4, filtered and concentrated to afford desired 6,7-dihydro-5H-[1]pyrindine 1-oxide (0.6 g). LCMS (m/z): 136.

後処理

  1. customto come to rt
  2. washwashed with water, aq NaHCO3, brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-5f949f76b1e847f79d06363480c08628
出典データセット
uspto-grants-2013_02
特許番号
US08383644B2

関連ノート

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