Hydrochloric Acid → HCID 66719276、化合物

HRID 391862ノート

反応式

HRID 391862 の反応式
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][C@@H:7]([C:12]([OH:14])=[O:13])[NH:8][CH2:9]2)=[CH:4][CH:3]=1.[ClH:15].[CH3:16]O>>[ClH:15].[CH3:16][O:13][C:12]([C@@H:7]1[CH2:6][C:5]2[C:10](=[CH:11][C:2]([OH:1])=[CH:3][CH:4]=2)[CH2:9][NH:8]1)=[O:14]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2733173(3S)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

生成物 1

HCID 66719276HCID 66719276、化合物

反応条件

温度
70 °C

実験手順

To a solution of (S)-7-hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (19.3 g) in 100 mL MeOH was added hydrochloric acid (100 mL, 4M solution in dioxane) at room temperature and the reaction mixture was heated to reflux and stirred at 70° C. for 16 hours. After completion of the reaction the reaction mixture was concentrated in vacuo to give (S)-7-hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester hydrochloride salt with quantitative yield. The product was used in the next step without further purification.

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux
  3. customAfter completion of the reaction the reaction mixture
  4. concentrationwas concentrated in vacuo

出典と根拠

ORDレコード
ord-4b00211f4eba4349a555352ab81ff9da
出典データセット
uspto-grants-2013_02
特許番号
US08383644B2

反応ノート

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