反応式
Cl.Cl.COC(=O)[C@@H:6]([NH:23][C:24]([C@@H:26]1[CH2:35][C:34]2[CH:33]=[C:32]3[O:36][CH2:37][C@H:38]([C:40]4[CH:45]=[CH:44][C:43]([O:46][CH2:47][CH:48]5[CH2:53][CH2:52][CH2:51][CH2:50][CH2:49]5)=[CH:42][CH:41]=4)[O:39][C:31]3=[CH:30][C:29]=2[CH2:28][NH:27]1)=[O:25])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]2[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[C:16]=2[CH3:22])=[CH:10][CH:9]=1.Cl[C:56]([C:58]1[CH:59]=[C:60]([O:64]C(=O)C)[CH:61]=[CH:62][CH:63]=1)=[O:57].[C:68]([O-:71])(O)=[O:69].[Na+]>CCOC(C)=O>[CH:48]1([CH2:47][O:46][C:43]2[CH:42]=[CH:41][C:40]([C@H:38]3[CH2:37][O:36][C:32]4=[CH:33][C:34]5[CH2:35][C@@H:26]([C:24]([NH:23][C@@H:6]([CH2:7][C:8]6[CH:9]=[CH:10][C:11]([O:14][C:15]7[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[C:16]=7[CH3:22])=[CH:12][CH:13]=6)[C:68]([OH:71])=[O:69])=[O:25])[N:27]([C:56](=[O:57])[C:58]6[CH:63]=[CH:62][CH:61]=[C:60]([OH:64])[CH:59]=6)[CH2:28][C:29]=5[CH:30]=[C:31]4[O:39]3)=[CH:45][CH:44]=2)[CH2:53][CH2:52][CH2:51][CH2:50][CH2:49]1参加物
5
反応物 3
生成物 1
試薬・触媒・溶媒 1
実験手順
(S)-2-{[(3S,8S)-3-(4-Cyclohexylmethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl]-amino}-3-[4-(2,3-dimethyl-pyridin-4-yloxy)-phenyl]-propionic acid methyl ester bis hydrochloride and excess acetic acid 3-chlorocarbonyl-phenyl ester were reacted in a biphasic mixture of EtOAc and saturated aqueous NaHCO3. The resulting compound was hydrolyzed according to General Procedure B to give the title compound (15 mg). LCMS (m/z) 813.
出典と根拠
- ORDレコード
- ord-346c41a4bacf4bfd9250d63fedc68b63
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08383644B2
関連ノート
読み込み中…