関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyrazine, 2-chloro-3-methyl- | HCID 66769 | — |
| 反応物 | [1-(2-Aminoethyl)piperidin-4-yl]methanol | HCID 19104142 | — |
| 生成物 | 1-[2-[(3-Methyl-2-pyrazinyl)amino]-ethyl]4-piperidinemethanol | HCID 10933938 | 29% |
反応手順
A mixture of 1-(2-amino-ethyl)-4-piperidinemethanol (5.2 g), 2-chloro-3-methyl-pyrazine (5.0 g) and CaO (4.5 g) was stirred for 20 hours at 120° C. The reaction mixture was cooled and purified by column chromatography over silica gel (eluent: CH2Cl2/(CH3OH/NH3) 92/8). The pure fractions were collected and the solvent was evaporated, yielding 2.3 g (29%) 1-[2-[(3-methyl-2-pyrazinyl)amino]-ethyl]4-piperidinemethanol (intermediate 1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06800628B2 |
|---|
| 出典データセット | uspto-grants-2004_10 |
|---|
| ORD ID | ord-95aee6ebb4c74eada13a147ef5fdef2b |
|---|
| 出典メモ | uspto-grants-2004_10 |
|---|
