2-Aminothiophenol → 2-(Chloromethyl)benzothiazole

HRID 3921

反応式

HRID 3921 の反応式
[Cl:1][CH2:2][C:3](OCC)(OCC)OCC.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[SH:20]>C(Cl)Cl>[Cl:1][CH2:2][C:3]1[S:20][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:13]=1

参加物

4

反応物 2

HCID 87132-AminothiophenolHCID 3059222-Chloro-1,1,1-triethoxyethane

生成物 1

HCID 3049782-(Chloromethyl)benzothiazole収率 91.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 2-chloro-1,1,1-triethoxyethane (5.9 g) and 2-aminothiophenol (2.5 g) was heated at 80° C. for 15 minutes. After cooling to room temperature, it was dissovled in methylene chloride (30 ml) and the resulting solution was washed with 3N HCl (10 ml) and then with water (20 ml). The organic portion was evaporated and the residue chromatographed over silica gel to obtain 2-chloromethylbenzothiazole (3.35 g; 90% yield), m.p. 34° C.

後処理

  1. washthe resulting solution was washed with 3N HCl (10 ml)
  2. customThe organic portion was evaporated
  3. customthe residue chromatographed over silica gel

出典と根拠

ORDレコード
ord-7628ca281c8a4d939d7e63b118d19a45
出典データセット
uspto-grants-1988_02
特許番号
US04723010

関連ノート

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