2-Aminothiophenol → 2-(Chloromethyl)benzothiazole
反応式
[Cl:1][CH2:2][C:3](OCC)(OCC)OCC.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[SH:20]>C(Cl)Cl>[Cl:1][CH2:2][C:3]1[S:20][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:13]=1参加物
4
実験手順
A solution of 2-chloro-1,1,1-triethoxyethane (5.9 g) and 2-aminothiophenol (2.5 g) was heated at 80° C. for 15 minutes. After cooling to room temperature, it was dissovled in methylene chloride (30 ml) and the resulting solution was washed with 3N HCl (10 ml) and then with water (20 ml). The organic portion was evaporated and the residue chromatographed over silica gel to obtain 2-chloromethylbenzothiazole (3.35 g; 90% yield), m.p. 34° C.
後処理
- washthe resulting solution was washed with 3N HCl (10 ml)
- customThe organic portion was evaporated
- customthe residue chromatographed over silica gel
出典と根拠
- ORDレコード
- ord-7628ca281c8a4d939d7e63b118d19a45
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04723010
反応ノート
読み込み中…