Sulfuric Acid → N-methylaspartic acid sulfate
反応式
[CH3:1][NH:2][C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][C:5]([OH:7])=[O:6].[S:11](=[O:15])(=[O:14])([OH:13])[OH:12]>O>[S:11]([OH:15])([OH:14])(=[O:13])=[O:12].[CH3:1][NH:2][C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][C:5]([OH:7])=[O:6]参加物
4
実験手順
10.7 g of N-methylaspartic acid was placed in a 250 ml round-bottom flask, and 100 ml of water was added to the flask and stirred for 30 minutes by using a magnetic stirrer. 7.12 g of concentrate sulfuric acid (concentration: 98%) was slowly dropped into the flask under stirring, and stirred for additional 2 hours after dropping. After the reaction, the reaction solution was concentrated, azeotroped with 100 ml of toluene to further remove the water and dried under vacuum to obtain 17 g of N-methylaspartic acid sulfate as yellow oil (Yield: 95.3%).
後処理
- stirringunder stirring
- stirringstirred for additional 2 hours
- customAfter the reaction
- concentrationthe reaction solution was concentrated
- customazeotroped with 100 ml of toluene
- customto further remove the water
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-53db3abe415442db8d58a89781f64b4c
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524895B2
反応ノート
読み込み中…