Sodium ethoxide → 4-Azaindole

HRID 392129

反応式

HRID 392129 の反応式
FC(F)(F)C([NH:5][C:6]1[C:7]([C:12]#[C:13][Si](C)(C)C)=[N:8][CH:9]=[CH:10][CH:11]=1)=O.[O-]CC.[Na+]>C(O)C>[NH:5]1[C:6]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[CH:12]=[CH:13]1

参加物

4

反応物 2

HCID 2723922Sodium ethoxideHCID 121468532,2,2-trifluoro-N-(2-trimethylsilanylethynylpyridin-3-yl)acetamide

生成物 1

HCID 92264-Azaindole

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2,2,2-trifluoro-N-(2-trimethylsilanylethynylpyridin-3-yl)acetamide (1.0 eq) and sodium ethoxide (5 eq.) in ethanol is heated at reflux temperature for 10 h, cooled and concentrated in vacuo. The resultant residue is purified by preparative reverse phase HPLC to give the title 4-azaindole.

後処理

  1. temperatureis heated
  2. temperatureat reflux temperature for 10 h
  3. temperaturecooled
  4. concentrationconcentrated in vacuo
  5. customThe resultant residue is purified by preparative reverse phase HPLC

出典と根拠

ORDレコード
ord-2930650ca1d249b885405ad26de4d25a
出典データセット
uspto-grants-2004_10
特許番号
US06800640B2

関連ノート

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