Sodium ethoxide → 4-Azaindole
反応式
FC(F)(F)C([NH:5][C:6]1[C:7]([C:12]#[C:13][Si](C)(C)C)=[N:8][CH:9]=[CH:10][CH:11]=1)=O.[O-]CC.[Na+]>C(O)C>[NH:5]1[C:6]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[CH:12]=[CH:13]1参加物
4
実験手順
A mixture of 2,2,2-trifluoro-N-(2-trimethylsilanylethynylpyridin-3-yl)acetamide (1.0 eq) and sodium ethoxide (5 eq.) in ethanol is heated at reflux temperature for 10 h, cooled and concentrated in vacuo. The resultant residue is purified by preparative reverse phase HPLC to give the title 4-azaindole.
後処理
- temperatureis heated
- temperatureat reflux temperature for 10 h
- temperaturecooled
- concentrationconcentrated in vacuo
- customThe resultant residue is purified by preparative reverse phase HPLC
出典と根拠
- ORDレコード
- ord-2930650ca1d249b885405ad26de4d25a
- 出典データセット
- uspto-grants-2004_10
- 特許番号
- US06800640B2
反応ノート
読み込み中…