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Triethylamine → Octahydroquinoline-1-carboxylic acid 3-chloropropylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Decahydroquinoline | HCID 92911 | — |
| 反応物 | Propane, 1-chloro-3-isocyanato- | HCID 166752 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Octahydroquinoline-1-carboxylic acid 3-chloropropylamide | HCID 66795223 | 84.6% |
反応手順
2.5 g (21 mmol) of 3-chloropropylisocyanate are dissolved in 150 mL of anhydrous THF and 6.4 mL (46 mmol) of Et3N. Once dissolved 3.4 mL (23 mmol) of decahydroquinoline are slowly added and it is refluxed for 18 h. AcOEt is then added and the resulting solution is sequentially washed with water, 1N HCl and brine. The organic phase is dried over anhydrous Na2SO4, it is filtered and the solvent is evaporated under reduced pressure yielding 4.6 g of intermediate IIIf.1. Method B: tr: 3.58 min; m/z: 259
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524894B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-815daed69aa74be79cf96e08165c9842 |
| 出典メモ | uspto-grants-2013_09 |