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Thiazolidine → 2-Difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thiazolidine | HCID 10444 | — |
| 反応物 | 2-Cyano-3-difluoromethoxyphenylsulfonyl chloride | HCID 58100767 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile | HCID 44199441 | — |
反応手順
54 mg of 2-cyano-3-difluoromethoxy-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 32 I of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by HPLC affords 35 mg of 2-difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524896B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-4e03c46cba5d4544802825dfbdd6204e |
| 出典メモ | uspto-grants-2013_09 |