化工社化工社 化学情報印刷レポート · 研究参考用
Thiazolidine → 2-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thiazolidine | HCID 10444 | — |
| 反応物 | 2-Cyano-3-fluorobenzene-1-sulfonyl chloride | HCID 20505212 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile | HCID 44218655 | — |
反応手順
440 mg of 2-cyano-3-fluoro-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 0.36 ml of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1) followed by acidic washing with a 1M HCl solution affords 318 mg of 2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524896B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-62d17e228e394a5fafc800d9e62ffeab |
| 出典メモ | uspto-grants-2013_09 |