Chloroacetyl chloride → 2-Chloromethyl-3-(2-chlorophenyl)-6,7-dimethoxy-3H-quinazolin-4-one

関与物質

役割	名称	HCID	仕込み量
反応物	Chloroacetyl chloride	HCID 6577	—
反応物	2-amino-N-(2-chlorophenyl)-4,5-dimethoxybenzamide	HCID 14127143	—
溶媒	Acetic Acid	HCID 176	—
生成物	2-Chloromethyl-3-(2-chlorophenyl)-6,7-dimethoxy-3H-quinazolin-4-one	HCID 22316558	46%

反応手順

Prepared according to Procedure B with 1a (2.95 g, 9.63 mmol) and chloroacetyl chloride (2.3 mL, 28.9 mmol) in acetic acid (30 mL). Purified by extraction from aq. K2CO3 and recrystallization from isopropanol to afford 1.61 g of a brown crystalline solid (46%). 1H NMR (CDCl3) δ: 7.59-7.66 (m, 2H); 7.45-7.56 (m, 3H); 7.20 (s, 1H); 4.37 (d, J=12 Hz, 1H), 4.08 (d, J=12 Hz, 1H); 4.04 (s, 3H); 4.00 (s, 3H). MS (ES): m/z 365.0 (M+).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06800620B2
出典データセット	uspto-grants-2004_10
ORD ID	ord-718b1bb7495d47d9a1187428e1041253
出典メモ	uspto-grants-2004_10