Chloroacetyl chloride → 6-Chloro-2-chloromethyl-3-(2-chlorophenyl)-3H-quinazolin-4-one

関与物質

役割	名称	HCID	仕込み量
反応物	Chloroacetyl chloride	HCID 6577	—
反応物	2-Amino-5-chloro-N-(2-chlorophenyl)benzamide	HCID 16781782	—
溶媒	Acetic Acid	HCID 176	—
生成物	6-Chloro-2-chloromethyl-3-(2-chlorophenyl)-3H-quinazolin-4-one	HCID 22316565	92%

反応手順

Prepared according to Procedure B with 1d (500 mg, 1.78 mmol) and chloroacetyl chloride (0.42 mL, 5.33 mmol) in acetic acid (10 mL). Purified by recrystallization from isopropanol to afford 555 mg of a yellow solid (92%). 1H NMR (CDCl3) δ: 8.27 (d, J=1.9 Hz, 1H); 7.74-7.78 (m, 2H); 7.60-7.66 (m, 1H); 7.48-7.57 (m, 3H); 4.37 (d, J=12 Hz, 1H), 4.07 (d, J=12 Hz, 1H). MS (ES): m/z 339.0 (M+).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06800620B2
出典データセット	uspto-grants-2004_10
ORD ID	ord-bb7804bba0ce49ab918a842af4422ca3
出典メモ	uspto-grants-2004_10