Sodium periodate → HCID 44218659、化合物

HRID 39225

反応式

HRID 39225 の反応式
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10]([N:13]2[CH2:17][CH2:16][S:15][CH2:14]2)(=[O:12])=[O:11])[C:3]=1[C:4]#[N:5].I([O-])(=O)(=O)=[O:19].[Na+]>CO.O>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10]([N:13]2[CH2:17][CH2:16][S:15](=[O:19])[CH2:14]2)(=[O:12])=[O:11])[C:3]=1[C:4]#[N:5]

参加物

5

反応物 2

HCID 23667635Sodium periodateHCID 442186552-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile

生成物 1

HCID 44218659HCID 44218659、化合物収率 70%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒2 回

実験手順

54 mg of 2-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile in 10 ml of methanol and 1 ml of water are treated with 45 mg of sodium periodate, and the mixture is stirred for 14 hours at room temperature. The reaction mixture is poured into water, and the aqueous layer is extracted three times with ethyl acetate. The combined organic layers are dried over sodium sulfate, filtered and concentrated in vacuo. Purification by reverse phase HPLC affords 40 mg of 2-Fluoro-6-(1-oxo-1 lambda*4*-thiazolidine-3-sulfonyl)-benzonitrile.

後処理

  1. extractionthe aqueous layer is extracted three times with ethyl acetate
  2. dry with materialThe combined organic layers are dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customPurification by reverse phase HPLC

出典と根拠

ORDレコード
ord-fd5234d09edb41feb82f3dd1a0012650
出典データセット
uspto-grants-2013_09
特許番号
US08524896B2

関連ノート

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