2-Amino-3-Hydroxypyridine → 2-(Chloromethyl)(1,3)oxazolo(4,5-b)pyridine

The commercially available 2-amino-3-hydroxypyridine (5.0 g) and diglyme (30 ml) were heated at 125° C. to obtain a solution. To this solution was added 2-chloro-1,1,1-triethoxyethane (9.9 g) and the mixture was held at 125° for 1 hour. The solution was cooled to room temperature and then decanted to remove a black byproduct residue. The filtrate was diluted with water (50 ml) and the resulting yellow precipitate was collected (1.5 g). A small sample was crystallized from isopropanol (m.p. 115°-118° C.).

1. customto obtain a solution
2. customdecanted
3. customto remove a black byproduct residue
4. additionThe filtrate was diluted with water (50 ml)
5. customthe resulting yellow precipitate was collected (1.5 g)
6. customA small sample was crystallized from isopropanol (m.p. 115°-118° C.)

ORDレコード

ord-3b3a232422e4466d95c7b4b7201b4772

出典データセット

uspto-grants-1988_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04723010