2-Amino-3-Hydroxypyridine → 2-(Chloromethyl)(1,3)oxazolo(4,5-b)pyridine
反応式
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[Cl:9][CH2:10][C:11](OCC)(OCC)OCC>COCCOCCOC>[Cl:9][CH2:10][C:11]1[O:8][C:7]2[C:2]([N:1]=1)=[N:3][CH:4]=[CH:5][CH:6]=2参加物
4
実験手順
The commercially available 2-amino-3-hydroxypyridine (5.0 g) and diglyme (30 ml) were heated at 125° C. to obtain a solution. To this solution was added 2-chloro-1,1,1-triethoxyethane (9.9 g) and the mixture was held at 125° for 1 hour. The solution was cooled to room temperature and then decanted to remove a black byproduct residue. The filtrate was diluted with water (50 ml) and the resulting yellow precipitate was collected (1.5 g). A small sample was crystallized from isopropanol (m.p. 115°-118° C.).
後処理
- customto obtain a solution
- customdecanted
- customto remove a black byproduct residue
- additionThe filtrate was diluted with water (50 ml)
- customthe resulting yellow precipitate was collected (1.5 g)
- customA small sample was crystallized from isopropanol (m.p. 115°-118° C.)
出典と根拠
- ORDレコード
- ord-3b3a232422e4466d95c7b4b7201b4772
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04723010
反応ノート
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