Ammonia → HCID 135674105、化合物

HRID 392311ノート

反応式

HRID 392311 の反応式
[O:1]=[C:2]1[NH:7][CH:6]=[CH:5][N:4]=[C:3]1[C:8]#[N:9].Cl.[NH3:11]>CO>[O:1]=[C:2]1[NH:7][CH:6]=[CH:5][N:4]=[C:3]1[C:8](=[NH:11])[NH2:9]

参加物

5

反応物 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 129137633-Oxo-3,4-dihydropyrazine-2-carbonitrile

生成物 1

HCID 135674105HCID 135674105、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

In 33 ml of methanol was dissolved 1.1 g of 3-oxo-3,4-dihydro-2-pyrazinecarbonitrile synthesized according to the description of J. Heterocycl. Chem., Vol. 19, Pages 1,397-1,402 (1982). While cooling the solution with ice, gaseous hydrogen chloride was introduced until saturation, after which the solution was stirred at the same temperature as above for 8 hours. The solvent was removed under reduced pressure, the residue thus obtained and dissolved in 55 ml of a 7 mol/L solution of ammonia in methanol at an ice-cooled temperature, and the solution thus obtained was stirred at the same temperature as above for 5 minutes. The solid product formed was collected by filtration to obtain 1.1 g of 3-oxo-3,4-dihydro-2-pyrazinecarboximidamide as a light yellow-colored solid product.

後処理

  1. customsynthesized
  2. additionwas introduced until saturation
  3. customThe solvent was removed under reduced pressure
  4. customthe residue thus obtained
  5. temperaturecooled temperature
  6. customthe solution thus obtained
  7. stirringwas stirred at the same temperature as above for 5 minutes
  8. customThe solid product formed
  9. filtrationwas collected by filtration

出典と根拠

ORDレコード
ord-b7f83cb9b6c54596aa57078c71f6063f
出典データセット
uspto-grants-2004_10
特許番号
US06800629B2

反応ノート

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