2-Pyrazinecarbonitrile, 3-azido-6-fluoro- → HCID 22662784、化合物

HRID 392347

反応式

HRID 392347 の反応式
[N:1]([C:4]1[C:5]([C:11]#[N:12])=[N:6][C:7]([F:10])=[CH:8][N:9]=1)=[N+]=[N-].[H][H]>CO.C(=O)([O-])[O-].[Ca+2].[Pd+2].C(=O)([O-])[O-]>[NH2:1][C:4]1[C:5]([C:11]#[N:12])=[N:6][C:7]([F:10])=[CH:8][N:9]=1

参加物

5

反応物 2

HCID 226627892-Pyrazinecarbonitrile, 3-azido-6-fluoro-HCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 22662784HCID 22662784、化合物収率 38.6%

試薬・触媒・溶媒 2

HCID 17803853Palladium on calcium carbonate触媒HCID 887Methanol溶媒

実験手順

In 5.0 mL of methanol was dissolved 0.24 g of 3-azido-6-fluoro-2-pyrazinecarbonitrile. After adding 0.075 g of lead-poisoned palladium-calcium carbonate at room temperature, hydrogen gas was introduced into the mixture at room temperature under a pressure of 1 atmosphere until the mixture became showing no further adsorption of hydrogen. After filtering off the insoluble matter from the reaction mixture, the filtrate was concentrated under reduced pressure. The residue thus obtained was purified by silica gel column chromatography [eluent: chloroform] to obtain 0.078 g of 3-amino-6-fluoro-2-pyrazinecarbonitrile as a yellow-colored solid product.

後処理

  1. filtrationAfter filtering off the insoluble matter from the reaction mixture
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue thus obtained
  4. customwas purified by silica gel column chromatography [eluent: chloroform]

出典と根拠

ORDレコード
ord-4480d28c37a24f63a3f2cd8e179bbf7d
出典データセット
uspto-grants-2004_10
特許番号
US06800629B2

関連ノート

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