関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Stannous Chloride | HCID 24479 | — |
| 反応物 | 2-Chloro-5-nitrobenzophenone | HCID 118591 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | (5-Amino-2-chlorophenyl)(phenyl)methanone | HCID 10489713 | — |
反応手順
2-Chloro-5-nitrobenzophenone (1.3 g,5.0 mmol), tin(II) chloride (4.5 g, 20 mmol), and ethanol (20 ml) were mixed and heated at 70° C. for 1 h. After cooling to room temperature, to the reaction mixture were added ice, EtOAc and aqueous NaHCO3 and it was stirred for 30 min. The organic layer was washed with brine and dried over MgSO4. Filtration and evaporation afforded 5-amino-2-Chlorobenzophenone. 1H NMR, 7.85(m,2H), 7.30-7.66 (m,3H7.20 (d,1H,J=8.8 Hz), 6.60-6.80 (m,2H). MS calcd 231.1; MS (M+1) 232.0.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06800651B2 |
|---|
| 出典データセット | uspto-grants-2004_10 |
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| ORD ID | ord-e1b29d11510c40008c7c6efbe6135613 |
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| 出典メモ | uspto-grants-2004_10 |
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