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Trifluoroacetic acid → 2-Oxoethyl butyrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 2,2-Dimethoxyethyl butyrate | HCID 11367300 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Oxoethyl butyrate | HCID 9898831 | — |
反応手順
Compound 43a (176 mg, 1.0 mmol) was dissolved in 8 mL of CH2Cl2 and 4 mL of TFA (containing 5% H2O) was added. The mixture was stirred for 30 min at room temperature. The solution was then concentrated in vacuo to give the product 44a that was used immediately for the next step. 1H NMR (400 MHz, CDCl3) δ 0.92 (m, 3H), 1.64 (m, 2H), 2.24 (t, J=7.04 Hz, 2H), 4.72 (s, 2H), 9.60 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524691B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-8994c8ce8da447d3a3b5ecdf901c759e |
| 出典メモ | uspto-grants-2013_09 |