Phosgene → Benzeneacetyl chloride, 4-(acetyloxy)-

HRID 39257

反応式

HRID 39257 の反応式
[C:1]([Cl:4])(Cl)=[O:2].[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15]O)=[CH:11][CH:10]=1)(=[O:7])[CH3:6]>C1(C)C=CC=CC=1>[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:1]([Cl:4])=[O:2])=[CH:11][CH:10]=1)(=[O:7])[CH3:6]

参加物

4

反応物 2

HCID 6371PhosgeneHCID 959064-Acetoxybenzyl alcohol

生成物 1

HCID 182488Benzeneacetyl chloride, 4-(acetyloxy)-

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

To a solution of phosgene in toluene (20% w/w, 2.2 mL, 4.2 mmol), cooled in an ice bath, was added dropwise a solution of 60 (321 mg, 1.9 mmol) in 2 mL of toluene. The mixture was stirred in the same bath, which was left to come to room temperature on its own. After 18 h, the mixture was concentrated in vacuo to give 61, which was used in the next step without further purification. 1H NMR (400 MHz, CDCl3) δ 2.30 (s, 3H), 5.28 (s, 2H), 7.13 (d, J=8.6 Hz, 2H), 7.42 (d, J=8.7 Hz, 2H).

後処理

  1. waitwas left
  2. customto come to room temperature on its
  3. concentrationthe mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-92490217d32c40b8aa54f432ecaf61a4
出典データセット
uspto-grants-2013_09
特許番号
US08524691B2

関連ノート

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