HCID 22018328、化合物 → HCID 178466003、化合物

HRID 392584ノート

反応式

HRID 392584 の反応式
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[C:9]([C:14]([C:19]1[N:20]=[CH:21][N:22](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:23]=1)([OH:18])[CH:15]([CH3:17])[CH3:16])[CH:8]=[CH:7]2)[CH3:2]>C(O)(=O)C.[C].[Pd]>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[C:9]([C:14]([C:19]1[N:20]=[CH:21][NH:22][CH:23]=1)([OH:18])[CH:15]([CH3:17])[CH3:16])[CH:8]=[CH:7]2)[CH3:2]

参加物

4

反応物 1

HCID 22018328HCID 22018328、化合物

生成物 1

HCID 178466003HCID 178466003、化合物収率 62.3%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 176Acetic Acid溶媒

反応条件

温度
60 °C

実験手順

1-(6-Ethoxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (0.60 g) was dissolved in acetic acid (10 ml) and 10% palladium carbon (0.2 g) was added and the mixture was stirred at 50° C. for 2 h and at 60° C. for 3 h under a hydrogen atmosphere. The catalyst was filtered off and the filtrate was concentrated to dryness. Recrystallization from THF-ethyl acetate gave the title compound (0.21 g) as a colorless crystalline powder.

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated to dryness
  3. customRecrystallization from THF-ethyl acetate

出典と根拠

ORDレコード
ord-c261a3552936472e9670ffeaec8f39bb
出典データセット
uspto-grants-2004_10
特許番号
US06800778B1

反応ノート

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