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Ethyl Bromide → 2-Ethoxybenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Bromide | HCID 6332 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Hydroxybenzonitrile | HCID 11907 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2-Ethoxybenzonitrile | HCID 576922 | 97.1% |
反応手順
25 g (210 mmol) of 2-hydroxylbenzonitrile are heated, together with 87 g of potassium carbonate and 34.3 g (314.8 mmol) of ethyl bromide, in 500 ml of acetone under reflux overnight. The solid is filtered off, the solvent is removed in vacuo and the residue is distilled in vacuo. 30.0 g (97%) of a colorless liquid are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06803365B2 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-30b68248ac194f4d8f029f3184997133 |
| 出典メモ | uspto-grants-2004_10 |