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Acetyl chloride → N-biphenyl-3-ylmethyl-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 3-(Aminomethyl)biphenyl | HCID 2760368 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-biphenyl-3-ylmethyl-acetamide | HCID 22660935 | 128.5% |
反応手順
C-Biphenyl-3-yl-methylamine (700 mg, 3.8 mmol) was dissolved in 38 mL of CH2Cl2. To this was added 38 mL of satd NaHCO3 (aq) followed by acetyl chloride (1.41 mL 19,8 mmol). The resulting mixture was stirred 45 min. The organic layer was separated, washed with satd NaCl, dried over Na2SO4, filtered and solvent removed under vacuum to yield 1.1 grams of N-biphenyl-3-ylmethyl-acetamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06803378B2 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-dedfeb76dab54b4b9c853a25bd0c6433 |
| 出典メモ | uspto-grants-2004_10 |