化工社化工社 化学情報印刷レポート · 研究参考用
Toluene → 4-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester chloroformate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester chloroformate | HCID 86655593 | — |
反応手順
To a solution of 4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (201 mg, 1.0 mmol) in THF (2 mL) was added a 20% solution of phosgene in toluene (358 μL, 1.7 mmol). The reaction was stirred at room temperature for 1 hour. The reaction was concentrated under reduced pressure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524764B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-b8798188cd69492386d462f7445ecae2 |
| 出典メモ | uspto-grants-2013_09 |