Triethylamine → (R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide

HRID 392931ノート

反応式

HRID 392931 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]([CH3:19])[CH2:11][NH:12][S:13]([CH:16]([CH3:18])[CH3:17])(=[O:15])=[O:14])=[CH:6][CH:5]=1)([O-])=O.C(N(CC)CC)C.[F:27][C:28]1[CH:29]=[C:30]([CH:34]=[C:35]([F:37])[CH:36]=1)[C:31](Cl)=[O:32]>C(Cl)Cl>[CH3:19][C@H:10]([C:7]1[CH:8]=[CH:9][C:4]([NH:1][C:31]([C:30]2[CH:29]=[C:28]([F:27])[CH:36]=[C:35]([F:37])[CH:34]=2)=[O:32])=[CH:5][CH:6]=1)[CH2:11][NH:12][S:13]([CH:16]([CH3:18])[CH3:17])(=[O:15])=[O:14]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 1456003,5-Difluorobenzoyl chlorideHCID 9965675(R)-N-(2-(4-nitrophenyl)propyl)propane-2-sulfonamide

生成物 1

HCID 9843690(R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide収率 80.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A 500 mL three necked round bottom flask equipped with a magnetic stirrer, thermometer, addition funnel and a positive nitrogen was charged with [(2R)-2-(4-nitrophenyl)propyl][(methylethyl)sulfonyl]amine (12.02 g, 46.85 mmol) and methylene chloride (200.0 mL). To this solution was added triethylamine (6.53 mL, 46.85 mmol) all at once. The solution was stirred for 10 minutes then added dropwise, neat 3,5-difluorobenzoyl chloride (5.9 mL, 46.85 mmol) over a period of 20 minutes. The reaction exothermed to reflux by the end of addition. Stirred to room temperature over the weekend for convenience. Quenched reaction with 1N HCl (100.0 mL) and separated lower organic layer. Washed the organic layer with 25% brine (70.0 mL) and dried with anhydrous magnesium sulfate. Filtered precipitates and concentrated filtrate to a tan oil (20.0 g). To this oil was added 1:1 ethyl acetate/hexane (125.0 mL) with stirring. A massive off white precipitate formed. The precipitate was then filtered and the cake washed with 1:1 ethyl acetate/hexane (50.0 mL). Precipitate was then dried in a house vacuum oven at 40° C. to provide N-[4-((1R)-1-methyl-2-{[(methylethyl)sulfonyl]amino}ethyl)phenyl](3,5-difluorophenyl)carboxamide (15.02 g, 80.9%); 1H NMR (CDCl3, 300 MHz) δ 1.26-1.27 (d, 6H), 1.29-1.30 (d,2H), 2.92 (m, 1H), 3.10 (m, 1H), 3.20 (1H), 3.3-3.4 (m, 1H), 7.0 (triplet, 1H), 7.20 (d, 2H), 7.40 (d, 2H), 7.60 (m, 2H), 8.19 (s, 1H); 13C NMR (CDCl3, 300 MHz) δ 17.19, 17.30, 19.75, 41.03, 50.99, 54.15, 107.68, 107.86, 108.08, 111.12, 111.33, 121.81, 128.59, 136.97, 138.77, 140.51, 162.62, 162.71, 164.12, 164.61, 164.71.

後処理

  1. additionthermometer, addition funnel
  2. additionthen added dropwise
  3. temperatureto reflux by the end of addition
  4. stirringStirred to room temperature over the weekend for convenience
  5. customQuenched
  6. customreaction with 1N HCl (100.0 mL)
  7. customseparated lower organic layer
  8. washWashed the organic layer with 25% brine (70.0 mL)
  9. dry with materialdried with anhydrous magnesium sulfate
  10. filtrationFiltered
  11. customprecipitates
  12. additionTo this oil was added 1:1 ethyl acetate/hexane (125.0 mL)
  13. stirringwith stirring
  14. customA massive off white precipitate formed
  15. filtrationThe precipitate was then filtered
  16. washthe cake washed with 1:1 ethyl acetate/hexane (50.0 mL)
  17. customPrecipitate was then dried in a house vacuum oven at 40° C.

出典と根拠

ORDレコード
ord-3fd5ba9c5e4b4cb9be004df68b3e3639
出典データセット
uspto-grants-2004_10
特許番号
US06803484B2

反応ノート

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