Methylhydrazine → 2-(1-Methylhydrazin-1-yl)pyrazine

2-Chloropyrazine (1 g, 8.3 mmol) and methylhydrazine (1.31 mL, 25 mmol) were mixed together in a flask fitted with a water condenser. After a few minutes an exotherm was observed. After 16 h the excess methylhydrazine was removed under reduced pressure. The cooled residue was stirred with aqueous sodium hydroxide solution (20 ml of 20%), and the resulting solution was extracted with ether (6×100 ml). The combined extracts were dried (K2CO3) and concentrated to give a light orange solid 370 mg of N-Methyl-N-pyrazin-2-yl-hydrazine.

1. customfitted with a water condenser
2. waitAfter a few minutes an exotherm was observed
3. customAfter 16 h the excess methylhydrazine was removed under reduced pressure
4. extractionthe resulting solution was extracted with ether (6×100 ml)
5. dry with materialThe combined extracts were dried (K2CO3)
6. concentrationconcentrated

ORDレコード

ord-28a4d71b5ba24896aa0d31b613757e0e

出典データセット

uspto-grants-2013_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08524764B2