Acetone → HCID 22648768、化合物
反応式
[CH:1]([C:4]([C:6]1[C:7]([C:12]([F:15])([F:14])[F:13])=[N:8][CH:9]=[N:10][CH:11]=1)=[O:5])([CH3:3])[CH3:2].CC(C)=O>C(O)C>[OH:5][CH:4]([C:6]1[C:7]([C:12]([F:15])([F:14])[F:13])=[N:8][CH:9]=[N:10][CH:11]=1)[CH:1]([CH3:2])[CH3:3]参加物
4
実験手順
25 g (115 mmol) of 5-isopropylcarbonyl-4-trifluorometylpyrimidine was dissolved in 100 ml of ethanol, and under cooling with ice, 6 g (69 mmol) of a borane-tert-butylamine complex was added, followed by stirring for 2 hours. Further, 20 ml of acetone was added, followed by stirring for 0.5 hour. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (developing solvent/n-hexane:ethyl acetate=1:1) to obtain 22 g (yield: 87%) of 5-(1-hydroxy-2-methylpropyl)-4-trifluoromethylpyrimidine as slightly yellow liquid (nD20=1.4481)
後処理
- temperatureunder cooling with ice, 6 g (69 mmol) of a borane-tert-butylamine complex
- additionwas added
- stirringby stirring for 0.5 hour
- distillationThe solvent was distilled off under reduced pressure
- customthe residue was purified by silica gel column chromatography (developing solvent/n-hexane:ethyl acetate=1:1)
出典と根拠
- ORDレコード
- ord-3ae17014e7cf4fd08e595c793e9019b8
- 出典データセット
- uspto-grants-2004_10
- 特許番号
- US06806230B1
反応ノート
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