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Methylamine → 7-Chloro-N-methyl-5-[(phenylmethyl)thio]-thiazolo[4 5-d]pyrimidin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | 5-(Benzylthio)-2-bromo-7-chlorothiazolo[4,5-d]pyrimidine | HCID 22052038 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 7-Chloro-N-methyl-5-[(phenylmethyl)thio]-thiazolo[4 5-d]pyrimidin-2-amine | HCID 22649116 | — |
反応手順
A solution of the product from Example 219 (0.3 g) in tetrahydrofuran (2 ml) containing methylamine (2.0 molar in THF: 0.81 ml) was stirred for 16 hours. The mixture was evaporated to dryness then purified (SiO2, ethyl acetate:dichloromethane 1:9 as eluant) to give the title compound (295 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06806273B1 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-b015c6be86a4456390b77af240e36bd0 |
| 出典メモ | uspto-grants-2004_10 |