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Diisopropylethylamine → 4-[2-[[7-Chloro-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-2-yl]amino]ethyl]-benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 4-(2-Aminoethyl)benzenesulfonamide | HCID 169682 | — |
| 反応物 | 5-(Benzylthio)-2-bromo-7-chlorothiazolo[4,5-d]pyrimidine | HCID 22052038 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-[2-[[7-Chloro-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-2-yl]amino]ethyl]-benzenesulfonamide | HCID 22649015 | 78.4% |
反応手順
A solution of the product from Example 219 (0.3 g) in tetrahydrofuran (2 ml) containing 4-(2-aminoethyl)benzenesulfonamide (0.161 g) and N-ethyldiisopropylamine (0.5 ml) was stirred for 16 hours. The mixture was evaporated to dryness then purified (SiO2, ethyl acetate:dichloromethane 4:6 as eluant) to give the title compound (310 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06806273B1 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-3c51001c0d2447609ac10a00ff064941 |
| 出典メモ | uspto-grants-2004_10 |