Formic Acid → HCID 136388388、化合物

HRID 393245ノート

反応式

HRID 393245 の反応式
[NH2:1][C:2]1[C:11]([C:12](=[O:14])[NH2:13])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([OH:15])[CH:3]=1.[CH:16](O)=O>>[OH:15][C:4]1[CH:3]=[C:2]2[C:11]([C:12](=[O:14])[NH:13][CH:16]=[N:1]2)=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7]

参加物

3

反応物 2

HCID 284Formic AcidHCID 22649192HCID 22649192、化合物

生成物 1

HCID 136388388HCID 136388388、化合物

実験手順

A mixture of methyl 4-amino-5-carbamoyl-2-hydroxybenzoate (5.4 g) and formic acid (50 ml) was heated to reflux for 1 hour. The mixture was evaporated. Toluene (75 ml) was added and the mixture was evaporated. The solid residue was washed with methanol and diethyl ether and dried to give methyl 7-hydroxy-4-oxo-3,4-dihydroquinazolin-6-carboxylate (5.2 g); NMR Spectrum: (DMSOd6) 4.9 (s, 3H), 7.09 (s, 1H), 7.39 (s, 1H), 8.5 (s, 1H).

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 1 hour
  3. customThe mixture was evaporated
  4. additionToluene (75 ml) was added
  5. customthe mixture was evaporated
  6. washThe solid residue was washed with methanol and diethyl ether
  7. customdried

出典と根拠

ORDレコード
ord-850cabeb028b4b338e7ad34e2df0c418
出典データセット
uspto-grants-2004_10
特許番号
US06806274B1

反応ノート

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