5-Benzyloxy-alpha,alpha,alpha',alpha'tetramethyl-1,3-benzenedimethanol → 3,5-Bis(1-methylethyl)phenol

HRID 393404

反応式

HRID 393404 の反応式
C([O:8][C:9]1[CH:10]=[C:11]([C:19]([CH3:22])([CH3:21])O)[CH:12]=[C:13]([C:15]([CH3:18])([CH3:17])O)[CH:14]=1)C1C=CC=CC=1>C(O)C.Cl.[C].[Pd]>[CH:15]([C:13]1[CH:14]=[C:9]([OH:8])[CH:10]=[C:11]([CH:19]([CH3:22])[CH3:21])[CH:12]=1)([CH3:18])[CH3:17]

参加物

5

反応物 1

HCID 99223705-Benzyloxy-alpha,alpha,alpha',alpha'tetramethyl-1,3-benzenedimethanol

生成物 1

HCID 931043,5-Bis(1-methylethyl)phenol収率 100.4%

試薬・触媒・溶媒 3

HCID 178418390HCID 178418390、化合物触媒HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

To a solution of 5-benzyloxy-α,α,α′,α′-tetramethyl-1,3-benzenedimethanol (22.9 g, 76 mmol) in ethanol (500 mL), concentrated hydrochloric acid (2.6 mL) and a 10% palladium-carbon catalyst (8.0 g) were added. Under hydrogen atmosphere, the mixture was stirred for 23 hours at 60° C. The reaction mixture was subjected to filtration, and the filtrate was concentrated under reduced pressure, to thereby yield 13.6 g of 3,5-diisopropylphenol as a solid (yield 100%). The solid was crystallized from hexane, to thereby yield colorless needles.

後処理

  1. filtrationThe reaction mixture was subjected to filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-8d6cd646ce274afb8122d80d40d75890
出典データセット
uspto-grants-2004_10
特許番号
US06806395B2

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