2,2'-(5-Hydroxy-1,3-phenylene)bis(propan-2-ol) → 3,5-Bis(1-methylethyl)phenol

HRID 393405

反応式

HRID 393405 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([C:12]([CH3:15])([CH3:14])O)[CH:5]=[C:6]([C:8]([CH3:11])([CH3:10])O)[CH:7]=1>C(O)C.Cl.[C].[Pd]>[CH:8]([C:6]1[CH:7]=[C:2]([OH:1])[CH:3]=[C:4]([CH:12]([CH3:15])[CH3:14])[CH:5]=1)([CH3:11])[CH3:10]

参加物

5

反応物 1

HCID 226603332,2'-(5-Hydroxy-1,3-phenylene)bis(propan-2-ol)

生成物 1

HCID 931043,5-Bis(1-methylethyl)phenol収率 97.3%

試薬・触媒・溶媒 3

HCID 178418390HCID 178418390、化合物触媒HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒

実験手順

To a solution of 5-hydroxy-α,α,α′,α′-tetramethyl-1,3-benzenedimethanol (20.0 g, 95.1 mmol) in ethanol (600 mL), concentrated hydrochloric acid (12.0 mL) and a 10% palladium-carbon catalyst (11.0 g) were added, and the mixture was stirred under hydrogen atmosphere for 22 hours at room temperature. The reaction mixture was subjected to filtration, and the filtrate was concentrated under reduced pressure, to thereby yield a white solid. The thus-obtained solid was crystallized from hexane, to thereby yield 16.5 g of 3,5-diisopropylphenol as colorless needles (yield 97.3%).

後処理

  1. filtrationThe reaction mixture was subjected to filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customto thereby yield a white solid
  4. customThe thus-obtained solid was crystallized from hexane

出典と根拠

ORDレコード
ord-72d8ee25c369452891b9524d80abc868
出典データセット
uspto-grants-2004_10
特許番号
US06806395B2

関連ノート

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