化工社化工社 化学情報印刷レポート · 研究参考用
N-Boc-p-toluenesulfonamide → tert-Butyl methyl(tosyl)carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Boc-p-toluenesulfonamide | HCID 688170 | — |
| 反応物 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | tert-Butyl methyl(tosyl)carbamate | HCID 22660067 | 85% |
反応手順
The crude fluorous DEAD reagent 22 was then used in Mitsunobu reactions with N-Boc-p-toluenesulfonamide. Once again, the standard mode of addition gave complete conversion with MeOH and the product, N-methyl-N-boc-p-toluenesulfonamide was isolated in 85% yield after FSPE. However, the allyl alcohol gave only trace conversion of the starting material. The organic fraction after FSPE was mostly starting material. These results are summarized in Table 7.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06806357B1 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-41a99d97be5e482e8c5bb07a1cfdf604 |
| 出典メモ | uspto-grants-2004_10 |