4-(2-methoxyphenoxy)aniline → 4-(2-Methoxyphenoxy)-anilino-3-bromo-6,7-dimethoxyquinoline

HRID 393569ノート

反応式

HRID 393569 の反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1Cl)=[CH:9][C:8]([O:13][CH3:14])=[C:7]([O:15][CH3:16])[CH:6]=2.[CH3:17][O:18][C:19]1[CH:32]=[CH:31][CH:30]=[CH:29][C:20]=1[O:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][CH:23]=1>C1(O)CCCCC1>[CH3:17][O:18][C:19]1[CH:32]=[CH:31][CH:30]=[CH:29][C:20]=1[O:21][C:22]1[CH:28]=[CH:27][C:25]([NH:26][C:3]2[C:2]([Br:1])=[CH:11][C:10]3[C:5](=[CH:6][C:7]([O:15][CH3:16])=[C:8]([O:13][CH3:14])[CH:9]=3)[N:4]=2)=[CH:24][CH:23]=1

参加物

4

反応物 2

HCID 11210674-(2-methoxyphenoxy)anilineHCID 226471943-Bromo-4-chloro-6,7-dimethoxyquinoline

生成物 1

HCID 536446864-(2-Methoxyphenoxy)-anilino-3-bromo-6,7-dimethoxyquinoline収率 37.5%

試薬・触媒・溶媒 1

HCID 7966Cyclohexanol溶媒

反応条件

温度
130 °C

実験手順

A mixture of 3-bromo-4-chloro-6,7-dimethoxyquinoline (302 mg) and 4-(2-methoxyphenoxy)-aniline (236 mg) in cyclohexanol (5 ml) was stirred and heated at 130° C. for 24 hours. The mixture was cooled to ambient temperature and then filtered. The crystals were washed first with methanol and then with diethyl ether and then dried to give 4-(2-methoxyphenoxy)-anilino-3-bromo-6,7-dimethoxyquinoline (Compound 2) (180 mg, 37%).

後処理

  1. temperatureThe mixture was cooled to ambient temperature
  2. filtrationfiltered
  3. washThe crystals were washed first with methanol
  4. dry with materialwith diethyl ether and then dried

出典と根拠

ORDレコード
ord-59f6b19c59f64d719f70bf1cc9adb12c
出典データセット
uspto-grants-2004_10
特許番号
US06809106B1

反応ノート

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