化工社化工社 化学情報印刷レポート · 研究参考用
Thionyl Chloride → 4-Chloro-6,7-dimethoxyquinoline hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 6,7-Dimethoxy-4-hydroxyquinoline | HCID 459611 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Chloro-6,7-dimethoxyquinoline hydrochloride | HCID 22646543 | — |
反応手順
A suspension of 6,7-dimethoxy-1,4-dihydroquinolin-4-one (3 g, 14 mmol), (J. Chem. Soc. 1940, 1209), in thionyl chloride (60 ml) and DMF (0.3 ml) was heated at reflux for 3 hours. Excess thionyl chloride was removed by evaporation and the residue azeotroped with toluene and washed with ether to give 4-chloro-6,7-dimethoxyquinoline hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06809097B1 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-d6a9307ea24f421bade5e071b6ab5a54 |
| 出典メモ | uspto-grants-2004_10 |