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HRID 393600作成日：2026年10月25日
5-Benzyloxy-2-fluoro-4-methylphenol → 4-(5-Benzyloxy-2-fluoro-4-methylphenoxy)-6-methoxy-7-(3-morpholinopropoxy)quinoline
https://huagongshe.com/reaction/393600
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Benzyloxy-2-fluoro-4-methylphenol | HCID 21991049 | — |
| 反応物 | 4-(3-((4-Chloro-6-methoxyquinolin-7-yl)oxy)propyl)morpholine | HCID 22265257 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 4-(5-Benzyloxy-2-fluoro-4-methylphenoxy)-6-methoxy-7-(3-morpholinopropoxy)quinoline | HCID 22646631 | 69% |
反応手順
4-Chloro-6-methoxy-7-(3-morpholinopropoxy)quinoline (250 mg, 0.74 mmol) was added to a solution of 5-benzyloxy-2-fluoro-4-methylphenol (257 mg 1.1 mmol) and potassium t-butoxide (125 mg, 1.1 mmol) in DMSO (3 ml) and the mixture heated at 160° C. for 1.5 hours. The mixture was allowed to cool and was partitioned between water and ethyl acetate. The organic layer was separated, washed with brine, dried (MgSO4), and the solvent removed by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol (95/5) to give 4-(5-benzyloxy-2-fluoro-4-methylphenoxy)-6-methoxy-7-(3-morpholinopropoxy)quinoline (105 mg, 69%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06809097B1 |
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| 出典データセット | uspto-grants-2004_10 |
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| ORD ID | ord-5a38eee06c30427a9e107d76bcd0c311 |
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| 出典メモ | uspto-grants-2004_10 |
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