関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Methoxy-5-nitrophenol | HCID 69471 | — |
| 反応物 | 2-Bromoethyl methyl ether | HCID 80972 | — |
| 触媒 | Potassium Iodide | HCID 4875 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Methoxy-3-(2-methoxyethoxy)nitrobenzene | HCID 10799305 | 98% |
反応手順
A mixture of 2-methoxy-5-nitrophenol (6 g, 35 mmol), 2-bromoethyl methyl ether (4 ml, 40 mmol), potassium carbonate (5.8 g, 40 mmol) and potassium iodide (0.5 g) in DMF (50 ml) was heated at 80° C. for 1 hour. The mixture was allowed to cool and poured into water (400 ml). The resulting precipitate was collected by filtration, washed with water and dried under vacuum to give 4-methoxy-3-(2-methoxyethoxy)nitrobenzene (7.75 g, 98%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06809097B1 |
|---|
| 出典データセット | uspto-grants-2004_10 |
|---|
| ORD ID | ord-559672ba6c0c414dbf5e79a7e1c891f3 |
|---|
| 出典メモ | uspto-grants-2004_10 |
|---|
