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5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione → 5-((4-Cyano-3-(3-morpholinopropoxy)anilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 152111 | — |
| 反応物 | 4-Cyano-3-(3-morpholinopropoxy)aniline | HCID 232800 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-((4-Cyano-3-(3-morpholinopropoxy)anilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 22646513 | 74.2% |
反応手順
4-Cyano-3-(3-morpholinopropoxy)aniline (2.5 g, 9.6 mmol) and 2,2-dimethyl-5-methoxymethylene-1,3-dioxane-4,6-dione (2.4 g, 13 mmol), (Montatsh. Chem. 1967, 98, 564), in ethanol (40 ml) was heated at reflux for 2 hours. The mixture was allowed to cool and the solid was collected by filtration to give 5-((4-cyano-3-(3-morpholinopropoxy)anilino)methylene)-2,2-dimethyl-1,3-dioxane-4.6-dione (2.96 g, 74%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06809097B1 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-7d50f465da16440aac820b9036fdad66 |
| 出典メモ | uspto-grants-2004_10 |