5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione → HCID 12354436、化合物

HRID 393658

反応式

HRID 393658 の反応式
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([NH2:11])[N:6]=1)(=[O:3])[CH3:2].[CH3:12][C:13]1([CH3:24])[O:18][C:17](=[O:19])[C:16](=[CH:20]OC)[C:15](=[O:23])[O:14]1>C(O)C>[C:1]([NH:4][C:5]1[N:6]=[C:7]([NH:11][CH:20]=[C:16]2[C:15](=[O:23])[O:14][C:13]([CH3:12])([CH3:24])[O:18][C:17]2=[O:19])[CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 1521115-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 37673452-Acetamido-6-aminopyridine

生成物 1

HCID 12354436HCID 12354436、化合物収率 22.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-acetamido-6-aminopyridine (2.9 g, 19 mmol), (Angew. chem. 1995, 107, 2589), and 2,2-dimethyl-5-methoxymethylene-1,3-dioxane-4,6-dione (4.28 g, 23 mmol), (Montatsh. Chem. 1967, 98, 564), in ethanol (75 ml) was stirred and heated at reflux for 5 hours. The mixture was allowed to cool and the precipitated product was collected by filtration and dried to give 5-((6-acetamido-2-pyridylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (1.3 g, 22%) as a yellow solid.

後処理

  1. temperatureheated
  2. temperatureat reflux for 5 hours
  3. temperatureto cool
  4. filtrationthe precipitated product was collected by filtration
  5. customdried

出典と根拠

ORDレコード
ord-36aac5d76a3d4e9380f883600b9eb6c4
出典データセット
uspto-grants-2004_10
特許番号
US06809097B1

関連ノート

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